A condition in which there is repeated episodes of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. It is of two types.
In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
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Paroxysmal Hemoglobinuria
June 8, 2008
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