Ezetemibi use has increased tremendously but adverse effects are being reported. ENHANCE study failed to show any benefit in its usage. Read this nice Editorial.
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Showing posts with label Lipidology. Show all posts
Showing posts with label Lipidology. Show all posts
LCAT activity and Sub Clinical Atherosclerosis
September 12, 2008
This is an interesting study that looked at relationship between LCAT activity and Carotid IMT. May be this will become marker of sub clinical atheromatous disease.Read the abstract of this study.
Posted by arif at 12:02 PM View Comments
Labels: Cardiovascular Disease, Lipidology
Move to top of post.Statin use and Cancer
September 7, 2008
Statins are not associated with a higher incidence of cancer, according to a meta-analysis of randomized controlled trials involving more than 97,000 patients.
Previous research reported an association between on-treatment low-density lipoprotein cholesterol (LDL-C) levels and cancer in patients on statins. Authors reviewed data from 15 trials of 51,797 patients given statins and 45,043 given placebo. The patients were followed for an average of about 4.5 years, or 437,017 patient years of follow-up. There were 5,752 cancer cases. Researchers reported their findings in the Journal of the American College of Cardiology.
Meta-regression analysis of the treatment arms of the studies showed an inverse association between treating LDL-C levels with statins and cancer, with 2.2 (95% CI, 0.7 to 3.6) fewer cancers per 1,000 person-years for every 10 mg/dL decrease in treating LDL (P= 0.006). The difference among control arms was 1.2 (95% CI, –0.2 to 2.7; P= 0.09). Meta-regression analysis showed that statins did not affect cancer risk for any levels of treatment.
The study also found a relationship between on-treatment LDL-C levels and cancer in patients not treated with statins.
Researchers concluded that statin-treated patients lower their LDL-C with no extra cancer risk.
Previous research reported an association between on-treatment low-density lipoprotein cholesterol (LDL-C) levels and cancer in patients on statins. Authors reviewed data from 15 trials of 51,797 patients given statins and 45,043 given placebo. The patients were followed for an average of about 4.5 years, or 437,017 patient years of follow-up. There were 5,752 cancer cases. Researchers reported their findings in the Journal of the American College of Cardiology.
Meta-regression analysis of the treatment arms of the studies showed an inverse association between treating LDL-C levels with statins and cancer, with 2.2 (95% CI, 0.7 to 3.6) fewer cancers per 1,000 person-years for every 10 mg/dL decrease in treating LDL (P= 0.006). The difference among control arms was 1.2 (95% CI, –0.2 to 2.7; P= 0.09). Meta-regression analysis showed that statins did not affect cancer risk for any levels of treatment.
The study also found a relationship between on-treatment LDL-C levels and cancer in patients not treated with statins.
Researchers concluded that statin-treated patients lower their LDL-C with no extra cancer risk.
Posted by arif at 9:46 AM View Comments
Labels: Cardiovascular Disease, Lipidology
Move to top of post.Lipid management at a glance
May 18, 2008
Posted by arif at 3:25 PM 0 comments
Labels: Cardiovascular Disease, Internal medicine, Lipidology
Move to top of post.Relevance Non-HDL Cholesterol in Patients With Diabetes
May 11, 2008
The following case illustrates how failure to consider the importanceof non-HDL cholesterol may result in the undertreatment of patientswith diabetes. R.R. is a 55-year-old man with a recent diagnosis of type 2 diabetes. He was previously noted to have impaired fasting glucose, for which he was prescribed a program of weight reduction and increased physical activity, as well as hypertension (140/85 mmHg), for which he was treated with an angiotensin receptor blocker. However, lifestyle changes are extraordinarily difficult for most people, and R.R. remained sedentary and obese ( BMI 39 kg/m2). His fasting bloodglucose level at diabetes diagnosis was 9.8mmol/l. If you want to learn more click here:
Posted by arif at 7:11 AM 0 comments
Labels: Diabetes, Internal medicine, Lipidology, Primary care
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