A new drug for treatment for HIV infection is long time due since the failure of vaccines.Inhibition of viral entry is not a new concept. It is, after all, one of the principle mechanisms of viral inhibition by the acquired immune response to infection, and viral entry is the step in viral life cycles that vaccine-induced antibodies are designed to block. Therefore, inhibition of viral entry was a logical target in the case of HIV-1.
Maraviroc is the first US Food and Drug Administration-approved drug from a new class of antiretroviral agents that targets a host protein, the chemokine receptor CCR5, rather than a viral target. Binding of maraviroc to this cell-surface protein results in blocking human immunodeficiency virus type 1 (HIV-1) attachment to the coreceptor and prevents the virus from entering CD4+ cells. Read this review...
Maraviroc is the first US Food and Drug Administration-approved drug from a new class of antiretroviral agents that targets a host protein, the chemokine receptor CCR5, rather than a viral target. Binding of maraviroc to this cell-surface protein results in blocking human immunodeficiency virus type 1 (HIV-1) attachment to the coreceptor and prevents the virus from entering CD4+ cells. Read this review...
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