Definition of Metabolic syndrome has evolved over period of ten years or so. Old NCEP, and revised NCEP and IDF guidelines are available now. This is an interesting French study that looked at All cause mortality comparison using different defintions of metabolic syndrome..Read more this abstract..
Showing posts with label Metabolic syndrome. Show all posts
Showing posts with label Metabolic syndrome. Show all posts
Obese and Healthy?
August 19, 2008
Better to Be Fat and Fit Than Skinny and Unfit, New York Times reports. This is in line with my previous post on Metabolically obese with normal weight.
MetSyn - disorder of Adipose Tissue Dysfunction
August 1, 2008
Metabolic Syndrome is defined by its various components, some lab measures and some measures of obesity. I strongle belive that this is not a syndrome but a continuum of a disorder. This condition starts with adipose tissue dysfunction and adipokines and cytokines production and excess fat going to muscles, liver and heart. Read more this interesting abstract..
Metabolic Syndrome and Diabetic Risk
June 5, 2008
Image details: Hot Summer Forecast For The UK served by picapp.com
The metabolic syndrome has been sometimes been linked to the development of diabetes mellitus 2 and cardiovascular disease, suggesting the syndrome represents a risk “greater than the sum of its parts.”
The syndrome has various definitions, but many have accepted the International Diabetes Foundation’s (IDF) definition; abdominal obesity plus two of the following: triglycerides > 150 mg/dL, HDL < 40, hypertension, and impaired fasting glucose. However there has been considerable debate whether metabolic syndrome truly is a distinct syndrome or just a group of conditions that happen to co-exist. Two prospective studies reported in the Lancet, the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) and the British Regional Heart Study, examined the supposed association of metabolic syndrome with the development of DM2 or CVD. In PROSPER, the metabolic syndrome was not associated with increased risk of cardiovascular disease (HR 1.07, 95% CI 0.86 to 1.32) but was highly associated with a greater risk of diabetes (HR 4.41, 95% CI 3.33 to 5.84). Curiously, neither the metabolic syndrome nor any of its components were significantly associated with the development of CVD in the PROSPER trial. The British Regional Heart Study (n= 2,737 males) did find a small association between metabolic syndrome and CVD (HR 1.27, 95% CI 1.04 to 1.56), but having the syndrome wasmore strongly predictive of the development of DM2 (HR 7.47, 95% CI 4.90 to 11.46). The new findings thereforeshow that the metabolic syndrome does not usefully predict a simultaneous risk of DM and CVD. The authors recommend that clinicians should focus on a global assessment of CVD risk based on previously validated criteria (for instance Framingham) rather than chasing down the rather cumbersome diagnosis of metabolic syndrome.
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