Yellow Nail Syndrome

From a Case series in Chest.
Yellow nail syndrome (YNS) is a rare disorder first described in 1964 by Samman and White, consisting of yellow nails with lymphedema and/or chronic respiratory manifestations. The respiratory manifestations are diverse and include pleural effusion, bronchiectasis, rhinosinusitis, chronic cough, or recurrent lung infections. The pathophysiology of the syndrome remains unclear, but various anatomic or functional lymphatic drainage abnormalities have been proposed as the underlying cause.