Glycemic Burden

In order to develop strategies that optimally address the glycemic burden in type 2 diabetes, it is informative to understand the relative contributions of FPG and PPG. Monnier et al did just that in a study published in 2003.
They enrolled 290 non-insulin- and non-acarbose-using patients with type 2 diabetes. Their plasma glucose concentrations were determined at fasting and during postprandial and postabsorptive periods. The areas under the curve above fasting glucose concentrations and above 6.1 mmol/L were calculated for further evaluation of the relative contributions of postprandial and fasting glucose increments to the overall glycemic burden.. The data were analyzed by quintiles of A1c.As shown in the Figure, the relative contribution of PPG decreased progressively from the lowest (69.7%) to the highest quintile of A1c